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Review ArticleConsiderations in individualizing prophylaxis in patients with haemophilia AL. A. Valentino*Article first published online: 8 APR 2014DOI: 10.1111/hae.12438© 2014 John Wiley & Sons Ltd Issue 
HaemophiliaEarly View (Online Version of Record published before inclusion in an issue)Additional InformationHow to CiteValentino, L. A. (2014), Considerations in individualizing prophylaxis in patients with haemophilia A. Haemophilia. doi: 10.1111/hae.12438Author InformationRush Hemophilia and Thrombophilia Center, Department of Pediatrics, Rush Children's Hospital and Rush University Medical Center, Chicago, IL, USA
* Correspondence: Leonard A. Valentino, MD; Rush Hemophilia and Thrombophilia Center; Rush University Medical Center; 1653 West Congress Parkway; Chicago, IL 60612-3833, USA.Tel.: +1 312 942 8114; fax: +1 312 942 8975; email: lvalentino@rush.edu
Publication HistoryArticle first published online: 8 APR 2014Manuscript Accepted: 10 MAR 2014Funded byBaxter Healthcare Corporation SEARCH Search Scope All contentPublication titlesIn this journalIn this issue Search String Advanced >Saved Searches > SEARCH BY CITATION Volume: Issue: Page: ARTICLE TOOLSGet PDF (189K)Save to My ProfileE-mail Link to this ArticleExport Citation for this ArticleGet Citation AlertsRequest Permissions AbstractArticleReferencesCited By View Full Article (HTML) Enhanced Article (HTML) Get PDF (189K) Keywords: FVIII ;haemophilia;individualizing;personalizing;prophylaxisSummary
Prophylaxis is considered optimal care for children and adults with severe haemophilia A because of its proven ability to reduce joint and other bleeding episodes. However, a ‘one size fits all’ approach to prophylaxis is not ideal, potentially leading to over-treatment in some individuals and under-treatment in others. Moreover, a generic plan fails to take into account a patient's lifestyle and personal preferences. This article reviews the factors contributing to bleeding risk and joint damage and uses case studies to illustrate how these contributors can be weighed to individualize the prophylactic regimen, thereby increasing the likelihood of therapeutic success.
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