Thursday, June 19, 2014

Why We Use The Term 'Mentoree'

mentoring softwareRecently, a peruser of our website contacted our President, Rene Petrin, to point out that we use the term 'mentoree' when in fact, he said, "the correct term is 'mentee.'"

Rene's response was this: "There is nothing that prevents anyone from being creative. I decided to use a word that specifies how my approach to mentoring is slightly different from others."

The term 'mentoree' illustrates that Rene's approach to mentoring is different from the status quo. Creative? Yes. Forward thinking? We think so.

This exchange prompted us to think about other words that were created (recently and not so recently) and have become part of not only main stream street language, but also bonafide, new words in the Oxford English dictionary.

Have you ever thought about where these words came from? Let's check out some cool examples together. Oh, and don't be shy. If you haven't heard these words, you can look up their definitions in the Oxford English Dictionary—which has a monthly and an annual list of "new words" as well as blog posts dedicated to new word entries. 

Popular street language

Twerk

Cyberbully

Retweet

Selfie

Googler

Fashion:

Maxxionista (TJ Maxx's spin on fashionista)

Chandelier earrings

Double denim

Pixie cut

Jeggings

Fauxhawk

Words Authors Invented

Nerd-Dr. Seuss

Tween-J.R.R. Tolkien

Alligator-William Shakespeare

Chortle-Lewis Carroll

Yahoo-Jonathan Swift

Serendipity-Horace Walpole

Utopia-Sir Thomas More

Gargantuan-Francois Rabelais

Buzzwords that helped techie's to gain notoriety:

SoLoMo

Web 2.0

Inbound Marketing

Angus Stevenson of Oxford Dictionaries Online said: “New words, senses, and phrases are added to Oxford Dictionaries Online when we have gathered enough independent evidence from a range of sources to be confident that they have widespread currency in English. Publishing online allows us to make the results of our research available more quickly than ever before. Each month, we add about 150 million words to our corpus database of English usage examples collected from sources around the world. We use this database to track and verify new and emerging words and senses on a daily basis. On average, we add approximately 1,000 new entries to Oxford Dictionaries Online every year, and this quarter’s update highlights some fascinating developments in the English language. Portmanteau words, or blends of words, such as phablet and jorts, remain popular, as do abbreviations, seen in new entries such as srsly and apols.”

So, hey, maybe if we can get enough folks to start referring to the term 'mentoree' we can get it added to the Oxford Dictionaries' new word entry list!

One more example that I must share...When I reached out to my marketing team and asked for their thoughts about new words, one of the women shared a story about when her kids were young. Here is a great example of how words express what we mean:
Jeanne said "When my kids were young, I was always rushing them 'Come on, come on, come on...' One day my daughter, who couldn't have been 3, sat down and said, "Mommy, I'm COMEONING." Best word ever to tell me she was doing her best to keep up, but I needed to slow down. Made-up word, sure, but it expressed exactly what she meant."
Rene didn't just make up a word to suit a purpose. The key idea behind the term 'mentoree' was to modify the existing word so that he could highlight his niche, business mentoring. So thank you to the gentleman who wrote the great comment! It spurred some fun conversation here at Management Mentors and gave us the opportunity to reminisce about Rene's unique approach to mentoring, to business, and to life! 
Do you have any "new words" to add to the list? Have you had experiences in the business world with new words? We'd love to hear them.

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Choose Village Earth on Colorado Gives Day – Donate on December 10th, 2013

CGD 2013_Master (1)

Support Village Earth on Colorado Gives Day!

During this time:On Tuesday, December 10, 2013, Coloradans will come together again to raise millions of dollars for nonprofits like ours. Last year, a remarkable $15.7 million was distributed to Colorado nonprofits. Help us reach our goal to raise $5000 during this 24-hour period.

 100 percent of your donation will come to us.When you give online any time on December 10, the value of your donation will be increased by the FirstBank Incentive Fund.Donate online at https://www.coloradogives.org/VillageEarth any time during the 24 hour period of December 10 to “give where you live!”

Pre-schedule Your Donation Today!
(Your credit card won’t be charged until Dec. 10th)


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Wednesday, June 18, 2014

Charter, private, and public schools work together in Boston

Charter, private, and public schools work together in Boston Skip to main page content

HOME CURRENT ISSUE PAST ISSUES FEEDBACK HELP Search PDK Submit Advanced Search User Name Password Sign In Charter, private, and public schools work together in Boston Diana Lam
DIANA LAM (dlam{at}conservatorylab.org) is the head of school at Conservatory Lab Charter School, Boston, Mass. Abstract A public, Catholic, and charter school in Boston all work together to share their strengths and learn from each other in an effort to deliver the best education for all of their students. The arrangement is called the School Performance Partnership, and it is a grantee of the Bill and Melinda Gates Foundation.

© 2014. « Previous | Next Article » Table of Contents This Article Phi Delta Kappan February 2014 vol. 95 no. 5 35-39 » AbstractFree Full Text Full Text (PDF) Classifications CHARTER SCHOOLS: Options & Expectations Services Tell a colleague about this article Alert me when this article is cited Alert me if a correction is posted Alert me when eletters are published Similar articles in this journal Similar articles in Web of Science Download to citation manager Responses Submit a response No responses published Citing Articles Load citing article information Citing articles via Web of Science Google Scholar Articles by Lam, D. PubMed Articles by Lam, D. Related Content Load related web page information Current Issue April 2014, 95 (7) Current Issue Alert me to new issues of Phi Delta Kappan ADVERTISE CONTACT US/PERMISSIONS EMAIL ALERTS INSTITUTIONAL SUBSCRIPTIONS PDK/GALLUP POLL PROFESSIONAL DEVELOPMENT GUIDES RSS FEEDS RSS Feeds WRITE FOR KAPPAN HighWire Press Logo Copyright © 2014 by PDK International

Print ISSN: 0031-7217 Online ISSN: 1940-6487

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Assessments can help Common Core teaching

Assessments can help Common Core teaching Skip to main page content

HOME CURRENT ISSUE PAST ISSUES FEEDBACK HELP Search PDK Submit Advanced Search User Name Password Sign In Assessments can help Common Core teaching Paul Bambrick-Santoyo Figure

PAUL BAMBRICK-SANTOYO is managing director of Uncommon Schools, Newark, N.J., and author of Great Habits, Great Readers: A Practical Guide to K-4 Reading in Light of the Common Core (Jossey-Bass, 2013).

Abstract The debate about the Common Core State Standards (CCSS) sets up a false dichotomy: Either learning is fun, or learning is a world of questionable assessment and bereft of joy. In reality, learning is at its most enjoyable when it proves to you that you can do something hard. This is a lesson that has been reinforced for generations. As educators in the age of the CCSS, we can make the CCSS our enemy or we can use it as an opportunity to open new depths of understanding for our students. They will be better served by the latter.

© 2014. « Previous | Next Article » Table of Contents This Article Phi Delta Kappan March 2014 vol. 95 no. 6 70-71 » AbstractFree Full Text Full Text (PDF) Classifications Series: IN PRACTICE LEADERSHIP KAPPAN COLUMNISTS Services Tell a colleague about this article Alert me when this article is cited Alert me if a correction is posted Alert me when eletters are published Similar articles in this journal Similar articles in Web of Science Download to citation manager Responses Submit a response No responses published Citing Articles Load citing article information Citing articles via Web of Science Google Scholar Articles by Bambrick-Santoyo, P. PubMed Articles by Bambrick-Santoyo, P. Related Content Load related web page information Current Issue April 2014, 95 (7) Current Issue Alert me to new issues of Phi Delta Kappan ADVERTISE CONTACT US/PERMISSIONS EMAIL ALERTS INSTITUTIONAL SUBSCRIPTIONS PDK/GALLUP POLL PROFESSIONAL DEVELOPMENT GUIDES RSS FEEDS RSS Feeds WRITE FOR KAPPAN HighWire Press Logo Copyright © 2014 by PDK International

Print ISSN: 0031-7217 Online ISSN: 1940-6487

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Rehabilitation improved walking ability for three haemophilia patients with inhibitors

Rehabilitation improved walking ability for three haemophilia patients with inhibitors - Shimokawa - 2014 - Haemophilia - Wiley Online Library Skip to Main Content Wiley Online Library Log in / Register Log In E-Mail Address Password Forgotten Password?

Remember Me RegisterInstitutional Login Home > Hematology > Hematology > Haemophilia > Vol 20 Issue 3 > Abstract JOURNAL TOOLS Get New Content Alerts Get RSS feed Save to My Profile Get Sample Copy Recommend to Your Librarian JOURNAL MENUJournal HomeFIND ISSUESCurrent IssueAll Issues FIND ARTICLES Early ViewMost Accessed GET ACCESS Subscribe / Renew FOR CONTRIBUTORS OnlineOpenAuthor GuidelinesSubmit an Article ABOUT THIS JOURNAL Society InformationNewsOverviewEditorial BoardPermissionsAdvertiseContact SPECIAL FEATURES Christine Lee Haemophilia Journal AwardVisit BloodMed.comWiley Job NetworkNew Books in Hematology & TransfusionVirtual IssueJobs Letter to the Editor

Rehabilitation improved walking ability for three haemophilia patients with inhibitorsA. Shimokawa1 andH. Takedani2,*Article first published online: 3 MAR 2014

DOI: 10.1111/hae.12389

© 2014 John Wiley & Sons Ltd

Issue

HaemophiliaHaemophiliaVolume 20, Issue 3, pages e222–e224, May 2014

Additional Information

How to CiteShimokawa, A. and Takedani, H. (2014), Rehabilitation improved walking ability for three haemophilia patients with inhibitors. Haemophilia, 20: e222–e224. doi: 10.1111/hae.12389

Author Information1

Department of Rehabilitation, National Hospital Organization Fukui National Hospital, Tsuruga, Japan

2

Department of Joint Surgery, IMSUT Research Hospital, The University of Tokyo, Tokyo, Japan

* Correspondence: Hideyuki Takedani, Department of Joint Surgery, Research Hospital, The Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-Ku, Tokyo 108-8639, Japan.
Tel.: +81 3 3443 8111; fax: +81 3 6409 2402;
e-mail: takedani@ims.u-tokyo.ac.jp

Publication HistoryIssue published online: 15 APR 2014Article first published online: 3 MAR 2014Manuscript Accepted: 17 JAN 2014 SEARCH Search Scope All contentPublication titlesIn this journalIn this issue Search String Advanced >Saved Searches > SEARCH BY CITATION Volume: Issue: Page: ARTICLE TOOLSGet PDF (69K)Save to My ProfileE-mail Link to this ArticleExport Citation for this ArticleGet Citation AlertsRequest Permissions AbstractArticleReferencesCited By View Full Article (HTML) Enhanced Article (HTML) Get PDF (69K)

No abstract is available for this article.

View Full Article (HTML) Enhanced Article (HTML) Get PDF (69K) More content like this Find more content: like this article Find more content written by:A. ShimokawaH. TakedaniAll Authors PublicationsBrowse by SubjectResources About UsHelpContact UsAgentsAdvertisersMediaPrivacyCookiesTerms & ConditionsSite Map Copyright © 1999-2014 John Wiley & Sons, Inc. All Rights Reserved. About WileyWiley.comWiley Job NetworkWiley

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Need a Last Minute Gift Idea? Send One of These Beautiful Donation Gift Cards.

This year, through our partner Globalgiving.org, you can make a tax-deductible contribution to one of Village Earth’s Grassroots Affiliates in honor of a friend or relative. Choose from two holiday gift designs or one birthday card design (see below).

12-12-2013 10-40-05 AM

Below is a list of Village Earth Affiliates that have this donation option available. Click on the their image to go their donation page at GlobalGiving.org.

12-12-2013 10-57-54 AM12-12-2013 10-54-00 AM

12-17-2013 10-01-13 AM

12-12-2013 1-05-26 PM

12-12-2013 10-58-23 AM12-12-2013 10-55-08 AM12-12-2013 10-56-23 AM

Once on the project page, to make a donation as a gift in honor of friend or family member, simply click on the 12-12-2013 10-47-01 AM  tab on the project page, enter the name of the person you would like to make the donation in honor or memory of, choose whether you would like to Print or Email the card (for those last-minute gifts) or send a physical card via USPS or FedEx. You then can choose from several different payment options.

12-12-2013 10-44-39 AM


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New Business Mentoring eBooks!

We have seven new mentoring eBooks, hot off the virtual presses. You can learn more about our eBooks by checking out our latest newsletter or by visiting our eBooks products page.

Business Mentoring: Communication Styles InstrumentBusiness Mentoring: Communication Styles Instrument AND Guide for Program ManagersGroup Mentoring: Facilitation Styles InstrumentGroup Mentoring: Mentoree Role PreferencesHow to Find a MentorMentor Readiness InstrumentMentoree Readiness Instrumentcorporate mentoring

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Being the change: An inner city school builds peace

Being the change: An inner city school builds peace Skip to main page content

HOME CURRENT ISSUE PAST ISSUES FEEDBACK HELP Search PDK Submit Advanced Search User Name Password Sign In Being the change: An inner city school builds peace Marnie W. Curry
MARNIE W. CURRY (mwcurry{at}ucsc.edu) is project director and researcher at the Center for Educational Research in the Interest of Underserved Students, University of California-Santa Cruz. Abstract This article describes an urban high school’s response to gun violence, chronicling how the school’s mission, full-service community orientation, and commitment to authentic cariño (caring) allowed students to respond to grief and tragedy and develop an ongoing peace building movement that seeks to transform students’ lives and the communities surrounding them.

© 2013. « Previous | Next Article » Table of Contents This Article Phi Delta Kappan December 2013/January 2014 vol. 95 no. 4 23-27 » AbstractFree Full Text Full Text (PDF) Classifications WHEN THE UNTHINKABLE STRIKES Services Tell a colleague about this article Alert me when this article is cited Alert me if a correction is posted Alert me when eletters are published Similar articles in this journal Similar articles in Web of Science Download to citation manager Responses Submit a response No responses published Citing Articles Load citing article information Citing articles via Web of Science Google Scholar Articles by Curry, M. W. PubMed Articles by Curry, M. W. Related Content Load related web page information Current Issue April 2014, 95 (7) Current Issue Alert me to new issues of Phi Delta Kappan ADVERTISE CONTACT US/PERMISSIONS EMAIL ALERTS INSTITUTIONAL SUBSCRIPTIONS PDK/GALLUP POLL PROFESSIONAL DEVELOPMENT GUIDES RSS FEEDS RSS Feeds WRITE FOR KAPPAN HighWire Press Logo Copyright © 2014 by PDK International

Print ISSN: 0031-7217 Online ISSN: 1940-6487

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Tuesday, June 17, 2014

Urgent Action: Fighting in S. Sudan Forces Village Earth Affiliate FOFCOD to Evacuate

Village Earth Global Affiliate, Forum for Community Change and Development (FOFCOD) in South Sudan, is carefully monitoring the situation in their country due factional violence that erupted this week after President Salva Kiir, accused his former vice president of attempting a military coup.We are in panic, We are planning to see how to evacuate some of our staff to neighboring countries Uganda until the situation comes to normal. “We are in panic, We are planning to see how to evacuate some of our staff to neighboring countries Uganda until the situation comes to normal.”

According to FOFCOD “the situation in Juba remains calm. Government security forces are in control. The town of Bor in Jonglei is no longer under the control of government security forces. Rather, it is controlled by troops who have apparently defected from and attacked the SPLA. Many persons have fled to the safety of the United Nations Mission in the Republic of South Sudan (UNMISS) compound. There is now a single, as yet unconfirmed, report of an attack on the compound. There has been fighting in Akobo, north-east of Bor, again apparently between factions of the SPLA. Many persons fled to the UNMISS compound for safety but it is now confirmed that the defecting troops have breached the UN site and there are reports of a fatality. There are reports of shooting, assumed to be fighting, to both the north and the south of Bentiu, in Unity State. No further details are available at this time. We are in panic, We are planning to see how to evacuate some of  our staff to neighboring countries Uganda until the situation comes to normal.”

Joining in 2013, FOFCOD is one of Village Earth’s newest Global Affiliates. The current conflict in South Sudan is a clear illustration of the urgency of their efforts to contribute to the national development through programs of Human rights, democracy, conflict resolution, health, education, livelihoods and food security, entrepreneurship, peace and justice in South Sudan.

Please Support FOFCOD in South Sudan

fund-project


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Matrix‐assisted laser desorption/ionization (MALDI) imaging mass spectrometry (IMS): peering into the cup of Jamshid

Matrix-assisted laser desorption/ionization (MALDI) imaging mass spectrometry (IMS): peering into the cup of Jamshid - Valentino - 2014 - Haemophilia - Wiley Online Library Skip to Main Content Wiley Online Library Log in / Register Log In E-Mail Address Password Forgotten Password?

Remember Me RegisterInstitutional Login Home > Hematology > Hematology > Haemophilia > Vol 20 Issue 3 > Abstract JOURNAL TOOLS Get New Content Alerts Get RSS feed Save to My Profile Get Sample Copy Recommend to Your Librarian JOURNAL MENUJournal HomeFIND ISSUESCurrent IssueAll Issues FIND ARTICLES Early ViewMost Accessed GET ACCESS Subscribe / Renew FOR CONTRIBUTORS OnlineOpenAuthor GuidelinesSubmit an Article ABOUT THIS JOURNAL Society InformationNewsOverviewEditorial BoardPermissionsAdvertiseContact SPECIAL FEATURES Christine Lee Haemophilia Journal AwardVisit BloodMed.comWiley Job NetworkNew Books in Hematology & TransfusionVirtual IssueJobs Commentary

Matrix-assisted laser desorption/ionization (MALDI) imaging mass spectrometry (IMS): peering into the cup of JamshidL. A. Valentino*Article first published online: 15 APR 2014

DOI: 10.1111/hae.12418

© 2014 John Wiley & Sons Ltd

Issue

HaemophiliaHaemophiliaVolume 20, Issue 3, pages 304–305, May 2014

Additional Information

How to CiteValentino, L. A. (2014), Matrix-assisted laser desorption/ionization (MALDI) imaging mass spectrometry (IMS): peering into the cup of Jamshid. Haemophilia, 20: 304–305. doi: 10.1111/hae.12418

Author Information

Hemophilia and Thrombophilia Center, RUSH University Medical Center, Chicago, IL, USA

* Correspondence: Leonard A. Valentino, Hemophilia and Thrombophilia Center, RUSH University Medical Center, Chicago, IL 60612-3833, USA.
Tel.: +1 312 942 8114; fax: +1 312 942 8975;
e-mail:lvalentino@rush.edu

Publication HistoryIssue published online: 15 APR 2014Article first published online: 15 APR 2014Manuscript Accepted: 24 FEB 2014 SEARCH Search Scope All contentPublication titlesIn this journalIn this issue Search String Advanced >Saved Searches > SEARCH BY CITATION Volume: Issue: Page: ARTICLE TOOLSGet PDF (72K)Save to My ProfileE-mail Link to this ArticleExport Citation for this ArticleGet Citation AlertsRequest Permissions AbstractArticleReferencesCited By View Full Article (HTML) Enhanced Article (HTML) Get PDF (72K) Keywords:biomarkers;haemophilia;joint disease;synovitisSummary

The complex process underlying the development of blood-induced joint disease remains mysterious. Novel technologies such as matrix-assisted laser desorption/ionization (MALDI) imaging mass spectrometry (IMS) to examine protein signatures may provide clues into the process.

View Full Article (HTML) Enhanced Article (HTML) Get PDF (72K) More content like this Find more content: like this article Find more content written by:L. A. Valentino PublicationsBrowse by SubjectResources About UsHelpContact UsAgentsAdvertisersMediaPrivacyCookiesTerms & ConditionsSite Map Copyright © 1999-2014 John Wiley & Sons, Inc. All Rights Reserved. About WileyWiley.comWiley Job NetworkWiley

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Lessons from a disaster on the Great Plains

Lessons from a disaster on the Great Plains Skip to main page content

HOME CURRENT ISSUE PAST ISSUES FEEDBACK HELP Search PDK Submit Advanced Search User Name Password Sign In Lessons from a disaster on the Great Plains Kathy Hintz
KATHY HINTZ (kathy.hintz{at}minotstateu.edu) is an assistant professor in education and social science at Minot State University, Minot, N.D. Abstract In June 2011, the Souris River flooded the city of Minot, N.D., destroying schools, businesses, and more than 4,000 houses. District administrators, staff, and teachers responded creatively to provide continuity for the students over a two-year period while three schools resided in temporary locations. The author details how the schools met these practical challenges and provides advice for schools on donations and creating a safe environment to help stressed children and staff focus on learning.

© 2013. « Previous | Next Article » Table of Contents This Article Phi Delta Kappan December 2013/January 2014 vol. 95 no. 4 28-32 » AbstractFree Full Text Full Text (PDF) Classifications WHEN THE UNTHINKABLE STRIKES Services Tell a colleague about this article Alert me when this article is cited Alert me if a correction is posted Alert me when eletters are published Similar articles in this journal Similar articles in Web of Science Download to citation manager Responses Submit a response No responses published Citing Articles Load citing article information Citing articles via Web of Science Google Scholar Articles by Hintz, K. PubMed Articles by Hintz, K. Related Content Load related web page information Current Issue April 2014, 95 (7) Current Issue Alert me to new issues of Phi Delta Kappan ADVERTISE CONTACT US/PERMISSIONS EMAIL ALERTS INSTITUTIONAL SUBSCRIPTIONS PDK/GALLUP POLL PROFESSIONAL DEVELOPMENT GUIDES RSS FEEDS RSS Feeds WRITE FOR KAPPAN HighWire Press Logo Copyright © 2014 by PDK International

Print ISSN: 0031-7217 Online ISSN: 1940-6487

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Update from Empowering Youth Cambodia – Student Profile Video | Humans of Phnom Penh

eycambodia-630x245

Cambodians have their own New Year holiday on April 13th which is the biggest holiday of the year, and next week the city of Phnom Penh will be quiet as people head to their families’ villages. Many EYC staff and students will be headed to their ‘homelands’ to welcome in the year of the horse and relax during the hottest month of the year (averaging 94°F / 34°C).

As EYC enters its 9th year we can see constant improvements in the maturity of our work and the abilities of our team.  We thank all of our donors who make our life-changing work possible, and assure you that our 620 students get significant benefits each week from our programs. We are happy to show you a great 5 minute video about one student’s life, Ratha: http://eycambodia.org/about/students/

A group of EYC students have started an interesting photoblog on Facebook calledHumans of Phnom Penh. It gives an insight into the daily lives of some of the capital’s residents through photography and short interviews and it was inspired by a similar blog, Humans of New York. Each student chooses individuals they meet in the city and who they find interesting to include in the project. Phnom Penh through Cambodian eyes. The blog is in Khmer and in English, take a look:
https://www.facebook.com/HoPPCambodia
Also, read the story about Humans of Phnom Penh in The Phnom Penh Post.

Happy Khmer New Year to everybody and thank you for all your support. Don’t forget April 16th!


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Laboratory aspects of von Willebrand disease: test repertoire and options for activity assays and genetic analysis

Laboratory aspects of von Willebrand disease: test repertoire and options for activity assays and genetic analysis - Castaman - 2014 - Haemophilia - Wiley Online Library Skip to Main Content Wiley Online Library Log in / Register Log In E-Mail Address Password Forgotten Password?

Remember Me RegisterInstitutional Login Home > Hematology > Hematology > Haemophilia > Vol 20 Issue > Abstract JOURNAL TOOLS Get New Content Alerts Get RSS feed Save to My Profile Get Sample Copy Recommend to Your Librarian JOURNAL MENUJournal HomeFIND ISSUESCurrent IssueAll Issues FIND ARTICLES Early ViewMost Accessed GET ACCESS Subscribe / Renew FOR CONTRIBUTORS OnlineOpenAuthor GuidelinesSubmit an Article ABOUT THIS JOURNAL Society InformationNewsOverviewEditorial BoardPermissionsAdvertiseContact SPECIAL FEATURES Christine Lee Haemophilia Journal AwardVisit BloodMed.comWiley Job NetworkNew Books in Hematology & TransfusionVirtual IssueJobs Review Article

You have free access to this contentLaboratory aspects of von Willebrand disease: test repertoire and options for activity assays and genetic analysisG. Castaman1, A. Hillarp2,* andA. Goodeve3Article first published online: 25 APR 2014

DOI: 10.1111/hae.12410

© 2014 John Wiley & Sons Ltd

Issue

HaemophiliaHaemophiliaSpecial Issue: State of the Art: WFH 2014 World Congress

Volume 20, Issue Supplement s4, pages 65–70, May 2014

Additional Information

How to CiteCastaman, G., Hillarp, A. and Goodeve, A. (2014), Laboratory aspects of von Willebrand disease: test repertoire and options for activity assays and genetic analysis. Haemophilia, 20: 65–70. doi: 10.1111/hae.12410

Author Information1

Department of Cell Therapy and Hematology, Hemophilia and Thrombosis Center, San Bartolo Hospital, Vicenza, Italy

2

Department of Clinical Chemistry, Malmo Centre for Thrombosis and Haemostasis, Skane University Hospital, Malmo, Sweden

3

Sheffield Diagnostic Genetics Service, Sheffield Children's NHS Foundation Trust & Haemostasis Research Group, Department of Cardiovascular Science, University of Sheffield, Sheffield, UK

* Correspondence: Andreas Hillarp, The Coagulation Laboratory, Department of Clinical Chemistry, Skane University Hospital, Jan Waldenströms gata 14, SE-20502 Malmo, Sweden.
Tel.: +46 734 226611; fax: +46 40 336255;
e-mail: andreas.hillarp@med.lu.se

Publication HistoryIssue published online: 25 APR 2014Article first published online: 25 APR 2014Manuscript Accepted: 24 FEB 2014 SEARCH Search Scope All contentPublication titlesIn this journalIn this issue Search String Advanced >Saved Searches > SEARCH BY CITATION Volume: Issue: Page: ARTICLE TOOLSGet PDF (105K)Save to My ProfileE-mail Link to this ArticleExport Citation for this ArticleGet Citation AlertsRequest Permissions AbstractArticleReferencesCited By View Full Article (HTML) Enhanced Article (HTML) Get PDF (105K) Keywords:genetic testing;laboratory diagnosis;ristocetin cofactor;von Willebrand disease;von Willebrand factor activitySummary

The deficiency or abnormal function of von Willebrand factor (VWF) causes von Willebrand disease (VWD), the most frequent inherited bleeding disorder. The laboratory diagnosis of VWD can be difficult as the disease is heterogeneous and an array of assays is required to describe the phenotype. Basic classification of quantitative (type 1 and 3) and qualitative (type 2) VWD variants requires determination of VWF antigenic (VWF:Ag) levels and assaying of VWF ristocetin cofactor (VWF:RCo) activity, determining the capacity of VWF to interact with the platelet GPIb-receptor. Knowing the VWF:RCo activity is essential for identifying, subtyping and monitoring VWD, but the assay is poorly standardized and many protocols do not fulfil the clinical need in all situations. This has led to the development of novel activity assays, independent of ristocetin, with enhanced assay characteristics. Results from the first independent clinical evaluations are promising, showing that they are reliable and suitable for VWD diagnosis. The qualitative type 2 VWF deficiency can be further divided into four different subtypes (A, B, M and N) using specific assays that explore other activities or the size distribution of VWF multimers. These methods are discussed herein. However, in a number of patients it may be difficult to correctly classify the VWD phenotype and genetic analysis may provide the best option to clarify the disorder, through mutation identification.

View Full Article (HTML) Enhanced Article (HTML) Get PDF (105K) More content like this Find more content: like this article Find more content written by:G. CastamanA. HillarpA. GoodeveAll Authors PublicationsBrowse by SubjectResources About UsHelpContact UsAgentsAdvertisersMediaPrivacyCookiesTerms & ConditionsSite Map Copyright © 1999-2014 John Wiley & Sons, Inc. All Rights Reserved. About WileyWiley.comWiley Job NetworkWiley

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